Design and Characterization of a Non-Linear Variable Inerter in Vehicle Suspension System

Inerter is a two-terminal component in suspension system such that the force at the two terminals is directly proportional to the relative acceleration of these two points. Studies have shown that the inerter can provide satisfactory vibration isolation for a number of suspension applications, including train suspension, building suspension and vehicle suspension. In the context of vehicle suspension, the existing passive inerter has been shown to provide benefits to vehicle dynamics performance measures, such as ride comfort and road holding ability. However, a basic passive inerter has fixed characteristic, and hence its potential is limited. This study overcome this limitation by incorporating variable inertia in inerter flywheel, however its non-linear characteristic needs to be determined. The method of achieving variable inertia in inerter flywheel is through introduction of movable masses or sliders attached with springs into inerter flywheel. The change of moment of inertia is caused by position change of sliders due to centrifugal force when the flywheel is rotating. Results showed that the proposed variable inerter exhibits a non-linear force-acceleration relationship with respect to its operating rotational speed. A vehicle suspension system equipped with a variable inerter is also able to further reduce vertical vehicle body acceleration and vehicle’s dynamic tire load when compared with vehicle suspension system without inerter and equipped with a passive inerter, which indirectly relates to a better vehicle ride and handling performance improvements. Hence, it can be proved that the proposed variable inerter is better than a passive inerter and is able to provide better ride comfort and road holding ability to a vehicle

Design and Characterization of a Non-Linear Variable Inerter in Vehicle Suspension System

Inerter is a two-terminal component in suspension system such that the force at the two terminals is directly proportional to the relative acceleration of these two points. Studies have shown that the inerter can provide satisfactory vibration isolation for a number of suspension applications, including train suspension, building suspension and vehicle suspension. In the context of vehicle suspension, the existing passive inerter has been shown to provide benefits to vehicle dynamics performance measures, such as ride comfort and road holding ability. However, a basic passive inerter has fixed characteristic, and hence its potential is limited. This study overcome this limitation by incorporating variable inertia in inerter flywheel, however its non-linear characteristic needs to be determined. The method of achieving variable inertia in inerter flywheel is through introduction of movable masses or sliders attached with springs into inerter flywheel. The change of moment of inertia is caused by position change of sliders due to centrifugal force when the flywheel is rotating. Results showed that the proposed variable inerter exhibits a non-linear force-acceleration relationship with respect to its operating rotational speed. A vehicle suspension system equipped with a variable inerter is also able to further reduce vertical vehicle body acceleration and vehicle’s dynamic tire load when compared with vehicle suspension system without inerter and equipped with a passive inerter, which indirectly relates to a better vehicle ride and handling performance improvements. Hence, it can be proved that the proposed variable inerter is better than a passive inerter and is able to provide better ride comfort and road holding ability to a vehicle

Macroscopic transport by synthetic molecular machines

Nature uses molecular motors and machines in virtually every significant biological process, but demonstrating that simpler artificial structures operating through the same gross mechanisms can be interfaced with—and perform physical tasks in—the macroscopic world represents a significant hurdle for molecular nanotechnology. Here we describe a wholly synthetic molecular system that converts an external energy source (light) into biased brownian motion to transport a macroscopic cargo and do measurable work. The millimetre-scale directional transport of a liquid on a surface is achieved by using the biased brownian motion of stimuli-responsive rotaxanes (‘molecular shuttles’) to expose or conceal fluoroalkane residues and thereby modify surface tension. The collective operation of a monolayer of the molecular shuttles is sufficient to power the movement of a microlitre droplet of diiodomethane up a twelve-degree incline.

A practical method for optimum seismic design of friction wall dampers

Friction control systems have been widely used as one of the efficient and cost effective solutions to control structural damage during strong earthquakes. However, the height-wise distribution of slip loads can significantly affect the seismic performance of the strengthened frames. In this study, a practical design methodology is developed for more efficient design of friction wall dampers by performing extensive nonlinear dynamic analyses on 3, 5, 10, 15, and 20-story RC frames subjected to seven spectrum-compatible design earthquakes and five different slip load distribution patterns. The results show that a uniform cumulative distribution can provide considerably higher energy dissipation capacity than the commonly used uniform slip load pattern. It is also proved that for a set of design earthquakes, there is an optimum range for slip loads that is a function of number of stories. Based on the results of this study, an empirical equation is proposed to calculate a more efficient slip load distribution of friction wall dampers for practical applications. The efficiency of the proposed method is demonstrated through several design examples

Class-Discriminative Weighted Distortion Measure for VQ-based Speaker Identification

We consider the distortion measure in vector quantization based speaker identification system. The model of a speaker is a codebook generated from the set of feature vectors from the speakers voice sample. The matching is performed by evaluating the distortions between the unknown speech sample and the models in the speaker database. In this paper, we introduce a weighted distortion measure that takes into account the correlations between the known models in the database. Larger weights are assigned to vectors that have high discriminating power between the speakers and vice versa

Evaluating intelligent interfaces for post-editing automatic transcriptions of online video lectures

Video lectures are fast becoming an everyday educational resource in higher education. They are being incorporated into existing university curricula around the world, while also emerging as a key component of the open education movement. In 2007, the Universitat Politècnica de València (UPV) implemented its poliMedia lecture capture system for the creation and publication of quality educational video content and now has a collection of over 10,000 video objects. In 2011, it embarked on the EU-subsidised transLectures project to add automatic subtitles to these videos in both Spanish and other languages. By doing so, it allows access to their educational content by non-native speakers and the deaf and hard-of-hearing, as well as enabling advanced repository management functions. In this paper, following a short introduction to poliMedia, transLectures and Docència en Xarxa (Teaching Online), the UPV s action plan to boost the use of digital resources at the university, we will discuss the three-stage evaluation process carried out with the collaboration of UPV lecturers to find the best interaction protocol for the task of post-editing automatic subtitles.Valor Miró, JD.; Spencer, RN.; Pérez González De Martos, AM.; Garcés Díaz-Munío, GV.; Turró Ribalta, C.; Civera Saiz, J.; Juan Císcar, A. (2014). Evaluating intelligent interfaces for post-editing automatic transcriptions of online video lectures. Open Learning: The Journal of Open and Distance Learning. 29(1):72-85. doi:10.1080/02680513.2014.909722S7285291Fujii, A., Itou, K., & Ishikawa, T. (2006). LODEM: A system for on-demand video lectures. Speech Communication, 48(5), 516-531. doi:10.1016/j.specom.2005.08.006Gilbert, M., Knight, K., & Young, S. (2008). Spoken Language Technology [From the Guest Editors]. IEEE Signal Processing Magazine, 25(3), 15-16. doi:10.1109/msp.2008.918412Leggetter, C. J., & Woodland, P. C. (1995). Maximum likelihood linear regression for speaker adaptation of continuous density hidden Markov models. Computer Speech & Language, 9(2), 171-185. doi:10.1006/csla.1995.0010Proceedings of the 9th ACM SIGCHI New Zealand Chapter’s International Conference on Human-Computer Interaction Design Centered HCI - CHINZ ’08. (2008). doi:10.1145/1496976Martinez-Villaronga, A., del Agua, M. A., Andres-Ferrer, J., & Juan, A. (2013). Language model adaptation for video lectures transcription. 2013 IEEE International Conference on Acoustics, Speech and Signal Processing. doi:10.1109/icassp.2013.6639314Munteanu, C., Baecker, R., & Penn, G. (2008). Collaborative editing for improved usefulness and usability of transcript-enhanced webcasts. Proceeding of the twenty-sixth annual CHI conference on Human factors in computing systems - CHI ’08. doi:10.1145/1357054.1357117Repp, S., Gross, A., & Meinel, C. (2008). Browsing within Lecture Videos Based on the Chain Index of Speech Transcription. IEEE Transactions on Learning Technologies, 1(3), 145-156. doi:10.1109/tlt.2008.22Proceedings of the 2012 ACM international conference on Intelligent User Interfaces - IUI ’12. (2012). doi:10.1145/2166966Serrano, N., Giménez, A., Civera, J., Sanchis, A., & Juan, A. (2013). Interactive handwriting recognition with limited user effort. International Journal on Document Analysis and Recognition (IJDAR), 17(1), 47-59. doi:10.1007/s10032-013-0204-5Torre Toledano, D., Ortega Giménez, A., Teixeira, A., González Rodríguez, J., Hernández Gómez, L., San Segundo Hernández, R., & Ramos Castro, D. (Eds.). (2012). Advances in Speech and Language Technologies for Iberian Languages. Communications in Computer and Information Science. doi:10.1007/978-3-642-35292-8Wald, M. (2006). Creating accessible educational multimedia through editing automatic speech recognition captioning in real time. Interactive Technology and Smart Education, 3(2), 131-141. doi:10.1108/1741565068000005

Relativistic effects and two-body currents in 2H(e⃗,e′p)n^{2}H(\vec{e},e^{\prime}p)n using out-of-plane detection

Measurements of the ${^2}H(\vec{e},e^{\prime}p)n$ reaction were performed using an 800-MeV polarized electron beam at the MIT-Bates Linear Accelerator and with the out-of-plane magnetic spectrometers (OOPS). The longitudinal-transverse, $f_{LT}$ and $f_{LT}^{\prime}$, and the transverse-transverse, $f_{TT}$, interference responses at a missing momentum of 210 MeV/c were simultaneously extracted in the dip region at Q$^2$=0.15 (GeV/c)$^2$. On comparison to models of deuteron electrodisintegration, the data clearly reveal strong effects of relativity and final-state interactions, and the importance of the two-body meson-exchange currents and isobar configurations. We demonstrate that these effects can be disentangled and studied by extracting the interference response functions using the novel out-of-plane technique.Comment: 4 pages, 4 figures, and submitted to PRL for publicatio

Single-molecule experiments in biological physics: methods and applications

I review single-molecule experiments (SME) in biological physics. Recent technological developments have provided the tools to design and build scientific instruments of high enough sensitivity and precision to manipulate and visualize individual molecules and measure microscopic forces. Using SME it is possible to: manipulate molecules one at a time and measure distributions describing molecular properties; characterize the kinetics of biomolecular reactions and; detect molecular intermediates. SME provide the additional information about thermodynamics and kinetics of biomolecular processes. This complements information obtained in traditional bulk assays. In SME it is also possible to measure small energies and detect large Brownian deviations in biomolecular reactions, thereby offering new methods and systems to scrutinize the basic foundations of statistical mechanics. This review is written at a very introductory level emphasizing the importance of SME to scientists interested in knowing the common playground of ideas and the interdisciplinary topics accessible by these techniques. The review discusses SME from an experimental perspective, first exposing the most common experimental methodologies and later presenting various molecular systems where such techniques have been applied. I briefly discuss experimental techniques such as atomic-force microscopy (AFM), laser optical tweezers (LOT), magnetic tweezers (MT), biomembrane force probe (BFP) and single-molecule fluorescence (SMF). I then present several applications of SME to the study of nucleic acids (DNA, RNA and DNA condensation), proteins (protein-protein interactions, protein folding and molecular motors). Finally, I discuss applications of SME to the study of the nonequilibrium thermodynamics of small systems and the experimental verification of fluctuation theorems. I conclude with a discussion of open questions and future perspectives.Comment: Latex, 60 pages, 12 figures, Topical Review for J. Phys. C (Cond. Matt

Caveolin-1 protects B6129 mice against Helicobacter pylori gastritis.

Caveolin-1 (Cav1) is a scaffold protein and pathogen receptor in the mucosa of the gastrointestinal tract. Chronic infection of gastric epithelial cells by Helicobacter pylori (H. pylori) is a major risk factor for human gastric cancer (GC) where Cav1 is frequently down-regulated. However, the function of Cav1 in H. pylori infection and pathogenesis of GC remained unknown. We show here that Cav1-deficient mice, infected for 11 months with the CagA-delivery deficient H. pylori strain SS1, developed more severe gastritis and tissue damage, including loss of parietal cells and foveolar hyperplasia, and displayed lower colonisation of the gastric mucosa than wild-type B6129 littermates. Cav1-null mice showed enhanced infiltration of macrophages and B-cells and secretion of chemokines (RANTES) but had reduced levels of CD25+ regulatory T-cells. Cav1-deficient human GC cells (AGS), infected with the CagA-delivery proficient H. pylori strain G27, were more sensitive to CagA-related cytoskeletal stress morphologies ("humming bird") compared to AGS cells stably transfected with Cav1 (AGS/Cav1). Infection of AGS/Cav1 cells triggered the recruitment of p120 RhoGTPase-activating protein/deleted in liver cancer-1 (p120RhoGAP/DLC1) to Cav1 and counteracted CagA-induced cytoskeletal rearrangements. In human GC cell lines (MKN45, N87) and mouse stomach tissue, H. pylori down-regulated endogenous expression of Cav1 independently of CagA. Mechanistically, H. pylori activated sterol-responsive element-binding protein-1 (SREBP1) to repress transcription of the human Cav1 gene from sterol-responsive elements (SREs) in the proximal Cav1 promoter. These data suggested a protective role of Cav1 against H. pylori-induced inflammation and tissue damage. We propose that H. pylori exploits down-regulation of Cav1 to subvert the host's immune response and to promote signalling of its virulence factors in host cells